Jun 28, 2019 how is treatment for leiomyosarcoma followed up. Believed to arise from or differentiate toward the arrector pili muscle. The best outcome occurs when it is taken out surgically with wide margins, early, while small and before it spreads. Cutaneous leiomyosarcoma clm is a very rare smooth muscle tumour that accounts for about 23% of all superficial soft tissue sarcomas. We report herein two cases of cutaneous leiomyosarcoma, one of dermal and other of subcutaneous vascular origin, confirmed by histology and immunohistochemistry. Malignant fibrous histiocytoma arising in a smallpox vaccination scar. The tumor arises either when an hhv 8infected organ is transplanted into someone. A benign tumor originating from the same tissue is termed leiomyoma. Cutaneous leiomyosarcoma of the flank is extremely rare and takes part in a group of infrequent and unknown tumors. Primary cutaneous leiomyosarcoma a histological and. Clinical and radiological followup of the patient during two years did not reveal recurrences. Pain and numbness are the most common symptoms in contrast to cutaneous. Approximately 10% of cases arise in the trunk, although the extremities are the most commonly affected.
While it has been believed that leiomyosarcomas do not arise from leiomyomas. Cutaneous leiomyosarcoma is primarily a lowgrade malignancy that affects elderly male caucasians. A 2006 report of a cutaneous leiomyosarcoma with myxoid alteration in a scar of a piloleiomyoma that had been excised 3 years previously probably does not represent a case of malignant transformation. They are most commonly found in the limbs, behind the abdomen retroperitoneum, gastrointestinal tract and the female reproductive system. Cutaneous leiomyosarcoma arising in a smallpox scar semantic. Primary cutaneous leiomyosarcoma pcl is a highlyinfrequent malignant tumor affecting the skin.
According to the american cancer society, at least 15,000 new cases of soft tissue sarcoma occur. Cutaneous leiomyosarcoma of the scalp springerlink. Kaposis sarcoma ks is a type of cancer that can form masses in the skin, lymph nodes. Cutaneous dermatoses and malignancies have occurred at the sites of vaccines. It spreads through the blood stream and can affect the. We herein report the case of a patient with a giant subcutaneous leiomyosarcoma arising. Superficial leiomyosarcoma is generally a disease of middle age, most frequently encountered between 40 and 60. The incidence of subcutaneous lms affecting the anterior abdominal wall is very rare. Although the smallpox and bcg vaccines are live, a component of the vaccines may. Generally, superficial leiomyosarcomas occur as a solitary, slowly growing lesion most commonly on proximal extremities, which coincide with the hair bearing areas. These muscles are involuntary you cant control them. Department of pathology and laboratory medicine, university of washington. In contrast to cutaneous leiomyosarcomas, these lesions may appear wellcircumscribed. Specifically, it refers to the thick layer of tissue below the epidermis the outer layer of your skin that forms the true skin, and contains your capillaries, nerve endings, sweat glands, hair follicles and various other structures.
Although they may arise anywhere in the body, they most frequently occur in the lower. Micrograph of promontory sign in kaposis sarcoma in patch stage. While it has been believed that leiomyosarcomas do not arise from leiomyomas, there are leiomyoma variants for which classification is evolving. Clinical course of nonvisceral soft tissue leiomyosarcoma in 225 patients from the scandinavian sarcoma group. Sarcoma was the pathology in 7 and recurrent breast cancer in. Primary cutaneous leiomyosarcoma is an uncommon malignant neoplasm with a predilection for the lower extremities. Symptoms of the following disorders can be similar to those of a leiomyosarcoma.
Similarly to what has been described in literature, our patient had a history of previous traumatism at the site of the tumor. Cutaneous leiomyosarcoma dermis is the medical term for your skin. Leiomyosarcoma develops in the smooth muscle cells, which are sometimes called involuntary muscles because they cause organs to contract without our control. This type of leiomyosarcoma has a more rapid growth rate than cutaneous leiomyosarcomas. Leiomyosarcoma primary care dermatology society uk. May 23, 2018 they can develop wherever smooth muscle is present. Although the development of various malignancies in scar tissue is well known, we report the first case of a clm developing in a small pox. Awareness of the particularly misleading features of this tumor, especially in elderly patients, is important. Subcutaneous leiomyosarcomas are rare tumors accounting for 1% to 2% of all superficial soft tissue malignancies. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be interpreted using reasonable medical judgment.
Health, general cancer research head and neck cancer diagnosis leiomyosarcoma medicine. Leiomyosarcoma mostly affects adults and are very rare in people under 20 years of age. The development of sarcomas in smallpox vaccination cars is very rare. Cutaneous leiomyosarcoma arising in a smallpox scar core. While leiomyosarcomas are due to genetic changes in the tumor cells, these. Conclusions this is the first report of a clm arising in a small pox scar. Skincolored indurated patch, plaque, follicular papules, or variably. Scanning power view of histology of leiomyosarcoma shows a poorly circumscribed tumour nodule which may be dermal based in the less common dermal leiomyosarcoma figure 1 or deeply infiltrating in the subcutaneous form. Download here free healthcaremagic app to ask a doctor all the information, content and live chat provided on the site is intended to be for. Case report open access cutaneous leiomyosarcoma arising in a smallpox scar robert a pol1, hilde dannenberg1, janlukas robertus2 and robert j van ginkel1 abstract background. Approximately 10% of cases arise in the trunk, although the. Soft tissue sarcoma sts accounts for approximately 1% of all cancers diagnosed annually in the united states. Cutaneous leiomyosarcoma clm is a very rare smooth muscle tumor arising from the dermis or subcutaneous tissue in the skin.
Cutaneous leiomyosarcomas are divided into a superficial dermal form, which is thought to arise from the arrector pili muscles, and a deep subcutaneous type, which. Leiomyosarcoma, is a malignant smooth muscle tumor. Why does my smallpox vaccination scar itch sometimes. Clm presents in persons of all ages but with a peak between 6070 years old. She had surgery in november for what the doctor thought was just a fibroid mass. Giant subcutaneous leiomyosarcoma of anterior abdominal wall. Adult with a red plaque at the site of a childhood vaccination scar. Cutaneous metastatic sarcoma, which represent less than 3% of all cutaneous metastases, has been described in association with epithelioid sarcoma, leiomyosarcoma arising in different organs. It is a rare dermalbased tumor for which treatment algorithms have been poorly defined.
It is a form of soft tissue cancer and appears specifically in the involuntary muscles. Leiomyosarcoma lms is a rare cancer that starts in smooth muscles that line organs like your stomach, bladder, and intestines. Cutaneous leiomyosarcoma atypical intradermal smooth muscle neoplasm. Jun 15, 2014 cutaneous leiomyosarcoma clm is a very rare smooth muscle tumor arising from the dermis or subcutaneous tissue in the skin. A retrospective study of four cases was undertaken to analyze. Cutaneous leiomyosarcoma on the trunk 1001 degree of histopathological displasia. Rare leiomyosarcoma in a burn scar sravya i, thomas j, sreekumar.
Leiomyosarcoma, or lms is a rare condition and yet there are a few thousand cases each year all over the world. Apr, 2016 cutaneous and subcutaneous leiomyosarcomas lms are uncommon neoplasms. We are unaware of genetic tests to help inform family members about leiomyosarcoma risks. Leiomyosarcomas comprise approximately 7% of all soft tissue sarcomas. Rapid growing superficial cutaneous leiomyosarcoma vol. Pdf chest wall reconstruction with porcine acellular dermal. Cutaneous leiomyosarcoma arising in a smallpox scar world. A case of leiomyosarcoma arising in a smallpox vaccination scar was also reported. This is the first report of a leiomyosarcoma arising in a smallpox vaccination scar. Leiomyosarcoma is an aggressive soft tissue sarcoma derived from smooth muscle cells typically of uterine, gastrointestinal or soft tissue origin. A retrospective study of four cases was undertaken to analyze clinicopathological characteristics and immunohistochemical profile of these neoplasms with special emphasis on prognosis.
An uncommon circa 100 cases reported in the world literature malignant neoplasm with a predilection for the hairbearing areas of the lower extremities. The risk of metastasis is greater than in cases of cutaneous leiomyosarcomas and the risk appears to increase with depth. You will have an edge for survival if you are under the supervision of a sarcoma oncologist, or a sarcoma oncology center. The best outcome occurs when it is taken out surgically with wide margins, early, while small and.
Case report open access cutaneous leiomyosarcoma arising. We report herein the case of a 31yearold man with a subcutaneous leiomyosarcoma, measuring 124. Cutaneous metastases and pagets disease of the skin. A leiomyosarcoma is a rare, malignant tumour displaying smooth muscle differentiation. The incidence is of less than 3% of the cutaneous softtissue sarcomas. Super ficial leiomyosarcoma expresses vimentin and smooth. We report herein two cases of cutaneous leiomyosarcoma, one of dermal and other of subcutaneous vascular origin. Superficial leiomyosarcoma originates in the superficial dermis or subcutaneous tissue and represents about 3% of the soft tissue sarcomas. Leiomyosarcomas presenting as a cutaneous malignancy in a burn.
Case report of a primary cutaneous leiomyosarcoma on the neck. Pdf cutaneous leiomyosarcoma arising in a smallpox scar. Cutaneous leiomyosarcoma may show different immunophenotypes, thus emphasizing the importance of using a large panel of antibodies smooth muscle actin, hhf35, desmin, vimentin, cytokeratins, and s100 protein in immunohistologic diagnosis. Aidsassociated kaposi sarcoma typically presents with cutaneous. Although they may arise anywhere in the body, they most frequently occur in the lower extremities. Answer after treatment for leiomyosarcoma, youll see your doctor for regular checkups. Although the development of various malignancies in scar tissue is well known, we report the first case of a clm developing in a small pox scar. It is a form of soft tissue cancer and appears specifically in the. Although the development of various malignancies in scar. This is the first report of a leiomyosarcoma arising in a smallpox. Cutaneous leiomyosarcoma arising in a smallpox scar.
Download here free healthcaremagic app to ask a doctor all the information, content and live chat provided on the site is intended to be for informational purposes only, and not a substitute for professional or medical advice. Specifically, it refers to the thick layer of tissue below the epidermis the outer layer of your skin that forms the true skin, and contains. We present the case of a 73yearold man with primary cutaneous leiomyosarcoma of the scalp who was admitted and treated for his condition in our department. Isolated cutaneous metastasis of uterine leiomyosarcoma. Leiomyomas are benign tumors arising from the smooth muscle. The differential diagnosis of histology includes atypical fibroxanthoma, dermatofibrosarcoma protuberans, angiosarcoma and spindle cell squamous cell carcinoma table 15,7. Leiomyosarcoma is a rare cancerous tumor that consists of smooth involuntary muscle cells. Cutaneous leiomyosarcomas are uncommon malignant tumors of smooth muscle.
Leiomyosarcoma genetic and rare diseases information. Leiomyosarcoma nord national organization for rare disorders. Rapid growing superficial cutaneous leiomyosarcoma of the face. Department of medicine, university of washington, usa. With the evolution of dermatologic surgery and cutaneous oncology, dermatologists have emerged as specialists for skin cancer management. The lesion was excised with adequate margins and a biopsy performed, after which results, the patient was admitted for further imaging and blood examinations. Retroperitoneal leiomyosarcoma is predominantly observed in elderly. Superficial leiomyosarcoma is generally a disease of middle age, most frequently encountered between 40 and 60 years of age. Jan 01, 2019 primary cutaneous leiomyosarcoma pcl is a highlyinfrequent malignant tumor affecting the skin. Printable subcutaneous leiomyosarcoma surgical pathology. Cutaneous leiomyosarcoma arising in a smallpox scar 2012.
In the skin, lesions are divided into the two subcategories of dermal and subcutaneous leiomyosarcomas due not only to their. Tumors with an origin in the dermis of skin are described as pcl tumors. The diagnosis of lowgrade leiomyosarcoma with free margins was made. Pain and numbness are the most common symptoms in contrast to cutaneous leiomyosarcomas, these lesions may appear well circumscribed. Cutaneous leiomyosarcoma clm is a very rare smooth muscle tumour that accounts for about. A giant subcutaneous leiomyosarcoma arising in the inguinal. Strattice sheet in the cases where the internal mammary. Smooth muscle cells make up the involuntary muscles, which are found in most parts of the. Case report of a primary cutaneous leiomyosarcoma on the. Case report open access cutaneous leiomyosarcoma arising in a. This website is intended for pathologists and laboratory personnel, who understand that medical information is imperfect and must be. Comparisons may be useful for a differential diagnosis.
Subcutaneous leiomyosarcoma is a rare condition that accounts for 1% to 2% of all superficial soft tissue malignancies. Leiomyosarcomas are rare malignant tumors of smooth muscles. Leiomyosarcoma nord national organization for rare. Leiomyosarcoma lms is a rare type of connective tissue cancer, accounting for 510% of all soft tissue sarcomas a type of cancer. Vaccineassociated feline sarcoma may provide insight into the. Leiomyosarcoma is a malignant tumour of smooth muscle.
Superficial leiomyosarcoma originates in the superficial dermis or. A giant subcutaneous leiomyosarcoma arising in the. In contrast to cutaneous leiomyosarcomas, these lesions may. Backgroundcutaneous leiomyosarcoma clm is a very rare smooth muscle tumour that accounts for about 23% of all superficial soft tissue sarcomas. Superficial leiomyosarcoma originates in the superficial. Sep 10, 2012 leiomyosarcomas are rare malignant tumors of smooth muscles. Rapid growing superficial cutaneous leiomyosarcoma of the. In subcutaneous lms, we observed that rates of recurrence, metastasis and mortality. The vast majority of these lesions occur in the uterus and gastrointestinal tract, and are rare in the skin. Cutaneous and subcutaneous leiomyosarcomas lms are uncommon neoplasms.
Cutaneous leiomyosarcoma may show different immunophenotypes, thus emphasizing the importance of using a large panel of antibodies smooth muscle actin, hhf35, desmin, vimentin, cytokeratins, and s. Bioprosthesis acelluar dermal matrix strattice would be a substitute to resist infection and provide stable coverage. Department of dermatology, university of washington, usa. It is usually diagnosed late or misdiagnosed, since it is a very rare tumor of the head and neck. If your cancer comes back, youll be treated again with. Both cases were treated with wide surgical excision, one with local recurrence. Primary cutaneous and subcutaneous leiomyosarcomas. Rapid growing superficial cutaneous leiomyosarcoma of the face kwang chul lee1, min sung kim. Sarcomas are malignant tumors arising from mesenchymal cell lines. Sarcoma subtypes nonuterine leiomyosarcoma leiomyosarcoma is a cancer of smooth muscle cells. Treatment goals depend on the type of cutaneous malignancy diagnosed.
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